色素性毛母质瘤：一种未被充分认识的变异型。
Pigmented pilomatricoma: an underrecognized variant.
作者信息
Ishida Mitsuaki, Okabe Hidetoshi
机构信息
Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science Shiga, Japan.
出版信息
Int J Clin Exp Pathol. 2013 Aug 15;6(9):1890-3. eCollection 2013.
The presence of melanin pigment and/or melanocytes in pilomatricoma has been rarely documented. In this study, we analyzed the incidence and clinicopathological features of pigmented pilomatricoma. Fifty-seven consecutive pilomatricoma cases from 53 Japanese patients were examined in this study. In fourteen cases (24.6%), pigmentation was observed in pilomatricoma. This variant equally affected in males and females, and the common locations were the upper arm and face. Proliferation of dendritic melanocytes was observed within basaloid cell nests in all cases, and melanin pigment was also present within the cytoplasm of the basaloid cells in 11 cases. Melanin pigment was also present in the shadow cells in 7 cases. The incidence of pigmented pilomatricoma as documented in previous reports is approximately 10%. However, our analysis revealed that pigmented pilomatricoma was found in 24.6% of Japanese cases of pilomatricoma, thus, this variant is not uncommon and may be under-recognized.
毛发瘤中黑色素沉着和/或黑素细胞的存在鲜有文献记载。在本研究中，我们分析了色素性毛发瘤的发病率及临床病理特征。本研究检查了来自53名日本患者的57例连续性毛发瘤病例。在14例（24.6%）毛发瘤病例中观察到色素沉着。该变异型在男性和女性中发病率相同，常见部位为上臂和面部。所有病例中均在基底样细胞巢内观察到树突状黑素细胞增生，11例基底样细胞的细胞质内也存在黑色素沉着。7例影子细胞中也存在黑色素沉着。既往报道的色素性毛发瘤发病率约为10%。然而，我们的分析显示，在日本毛发瘤病例中，色素性毛发瘤的发生率为24.6%，因此，该变异型并不罕见，可能未得到充分认识。
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