自催化模型的动力学，即酶作用于其一种底物的反应的耦合。

Kinetics of a model of autocatalysis, coupling of a reaction in which the enzyme acts on one of its substrates.

作者信息

Varón R, Havsteen B H, García M, Vázquez A

机构信息

Biochemisches Institut, Christian Albrechts Universität, Kiel, Germany.

出版信息

J Theor Biol. 1992 Jan 21;154(2):261-70. doi: 10.1016/s0022-5193(05)80407-2.

DOI:10.1016/s0022-5193(05)80407-2

PMID:1573907

Abstract

A global kinetic analysis is presented of a model of an enzyme autocatalytic process, to which a reaction is coupled, in which the enzyme acts upon one of its substrates. The kinetic equations of both the transient phase and the steady state are derived for this mechanism. In addition, we determine the corresponding kinetic equations for several particular cases which are characterized by certain relations between the rate constants. Finally, a kinetic data analysis is proposed for one of these particular cases. It can easily be extended to any of the other cases.

摘要

本文给出了一个酶自催化过程模型的全局动力学分析，该模型与一个反应耦合，其中酶作用于其一种底物。推导了该机制的瞬态阶段和稳态的动力学方程。此外，我们确定了几个特定情况的相应动力学方程，这些情况由速率常数之间的某些关系表征。最后，针对其中一个特定情况提出了动力学数据分析。它可以很容易地扩展到任何其他情况。