钯催化未活化烯烃的有氧氧化胺化反应。

Aerobic oxidative amination of unactivated alkenes catalyzed by palladium.

作者信息

Brice Jodie L, Harang Jenna E, Timokhin Vitaliy I, Anastasi Natia R, Stahl Shannon S

机构信息

Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA.

出版信息

J Am Chem Soc. 2005 Mar 9;127(9):2868-9. doi: 10.1021/ja0433020.

DOI:10.1021/ja0433020

PMID:15740119

Abstract

The first examples of palladium-catalyzed oxidative amination of unactivated alkyl olefins have been identified. To be successful, these reactions must be conducted under cocatalyst-free conditions that involve direct dioxygen-coupled turnover of the palladium catalyst. The oxidative amination products of norbornene and other cyclic alkenes implicate a cis-aminopalladation mechanism.

摘要

已发现钯催化未活化烷基烯烃氧化胺化反应的首例实例。要成功实现这些反应，必须在无共催化剂的条件下进行，且该条件涉及钯催化剂的直接双氧偶联周转。降冰片烯和其他环状烯烃的氧化胺化产物表明存在顺式氨基钯化机理。