光氧化还原催化和 Cu(II)-介导的自由基极性交叉促进高取代烯烃的烯丙基胺化反应。
Allylic Amination of Highly Substituted Alkenes Enabled by Photoredox Catalysis and Cu(II)-Mediated Radical-Polar Crossover.
机构信息
Department of Chemistry, University of Wisconsin─Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.
出版信息
Org Lett. 2023 Jun 30;25(25):4750-4754. doi: 10.1021/acs.orglett.3c01774. Epub 2023 Jun 22.
Abstract
Allylic amination reactions enable the conversion of alkene feedstocks into value-added products with significant synthetic versatility. Here we describe a method for allylic amination involving photoredox activation and Cu(II)-mediated radical-polar crossover. A range of structurally varied allylic amines can be accessed using this strategy. The regioselectivity of this process is complementary to those of conventional methods for allylic amination.
摘要
烯丙基胺化反应能够将烯烃原料转化为具有显著合成多功能性的增值产品。在这里，我们描述了一种涉及光氧化还原活化和 Cu(II)介导的自由基-极性交叉的烯丙基胺化方法。使用这种策略可以获得一系列结构变化的烯丙基胺。该过程的区域选择性与传统的烯丙基胺化方法互补。
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