Lee Suji, Coco Maria, Greenstein Stuart M, Schechner Richard S, Tellis Vivian A, Glicklich Daniel G
Renal Division, Montefiore Medical Center, Brinx, NY, USA.
Clin Transplant. 2005 Apr;19(2):162-7. doi: 10.1111/j.1399-0012.2005.00257.x.
It is unclear whether sirolimus, a newer immunosuppressive agent, widely used in renal transplantation, affects male sex hormone levels or sexual function.
Sex hormone profiles in male renal transplant recipients were obtained and compared between a sirolimus-treated group and a group not on sirolimus in a cross-sectional study. Both groups also completed a sexual dysfunction questionnaire.
Sixty-six subjects were evaluated, 32 in the sirolimus group and 34 in the control group. Total testosterone level was significantly lower in the sirolimus group than the control group (393.3 +/- 188 vs. 537.4 +/-232 pg/mL; p = 0.08) while follicle stimulating hormone and luteinizing hormone levels were significantly higher in the sirolimus group (12.8 +/- 14 vs. 6.0 +/- 5, p = 0.013; 10.9 +/- 14 vs. 4.7 +/- 4, p = 0.018, respectively). There was a significant negative correlation between 24-h sirolimus trough and total testosterone levels (p < 0.03). By multiple regression analysis, use of sirolimus was independently associated with decreased total testosterone level. There was no significant difference in subjective sexual dysfunction as assessed by questionnaire scores between the two groups. There was no correlation between questionnaire scores and total testosterone level.
Sirolimus is associated with decreased total testosterone levels in male renal transplant recipients. It is unclear whether sirolimus may affect other aspects of sexual function.
西罗莫司作为一种新型免疫抑制剂，广泛应用于肾移植，但它是否会影响男性激素水平或性功能尚不清楚。
在一项横断面研究中，获取男性肾移植受者的性激素谱，并比较西罗莫司治疗组和未使用西罗莫司组的情况。两组还完成了性功能问卷。
共评估了66名受试者，西罗莫司组32名，对照组34名。西罗莫司组的总睾酮水平显著低于对照组（393.3±188 vs. 537.4±232 pg/mL；p = 0.08），而西罗莫司组的促卵泡激素和促黄体生成素水平显著更高（分别为12.8±14 vs. 6.0±5，p = 0.013；10.9±14 vs. 4.7±4，p = 0.018）。西罗莫司24小时谷浓度与总睾酮水平之间存在显著负相关（p < 0.03）。通过多元回归分析，使用西罗莫司与总睾酮水平降低独立相关。两组间问卷评分评估的主观性功能障碍无显著差异。问卷评分与总睾酮水平之间无相关性。
西罗莫司与男性肾移植受者的总睾酮水平降低有关。尚不清楚西罗莫司是否会影响性功能的其他方面。
