Gurrera Ronald J, Salisbury Dean F, O'Donnell Brian F, Nestor Paul G, McCarley Robert W
Harvard Medical School, Department of Psychiatry, Boston MA, USA.
Psychiatry Res. 2005 Feb 28;133(2-3):215-28. doi: 10.1016/j.psychres.2004.09.009.
The relationship of the auditory P3 event-related potential to major personality dimensions and neuropsychological performance was examined in psychiatrically healthy men and women (28 male, 15 female) recruited from the community. An auditory oddball paradigm was used to collect P3 amplitude and latency data. Personality traits were measured with the NEO Five-Factor Inventory. Several Wechsler Adult Intelligence Scale-Revised (WAIS-R) subtests, the Digit Symbol Test, and the Trail Making Test comprised the neuropsychological tests. A multivariate statistical procedure (Partial Least Squares) was used to quantify the relationships between P3 variables and personality and neuropsychological performance variables. P3 amplitude was negatively related to Neuroticism and positively related to Extraversion, Openness, Agreeableness and Conscientiousness. Better neuropsychological performance was associated with greater P3 amplitude and earlier latency. Thus, greater P3 amplitude was associated with less deviant personality scores and better neuropsychological performance in healthy subjects. Earlier P3 latency was also associated with better neuropsychological performance. The physiological significance of these relationships is not yet clear, but these results suggest that neural assemblies indexed by P3 may subserve both elemental cognition and healthy personality function.
在从社区招募的精神健康的男性和女性（28名男性，15名女性）中，研究了听觉P3事件相关电位与主要人格维度和神经心理表现之间的关系。采用听觉Oddball范式收集P3波幅和潜伏期数据。使用NEO五因素问卷测量人格特质。几项韦氏成人智力量表修订版（WAIS-R）分测验、数字符号测验和连线测验构成了神经心理测验。采用多元统计程序（偏最小二乘法）来量化P3变量与人格及神经心理表现变量之间的关系。P3波幅与神经质呈负相关，与外向性、开放性、宜人性和尽责性呈正相关。更好的神经心理表现与更大的P3波幅和更早的潜伏期相关。因此，在健康受试者中，更大的P3波幅与较少的异常人格得分和更好的神经心理表现相关。更早的P3潜伏期也与更好的神经心理表现相关。这些关系的生理意义尚不清楚，但这些结果表明，由P3索引的神经组件可能有助于基本认知和健康的人格功能。
