Neame R, Hammond A
Department of Rheumatology, Derbyshire Royal Infirmary, London Road, Derby DE1 2QY, UK.
Rheumatology (Oxford). 2005 Jun;44(6):762-7. doi: 10.1093/rheumatology/keh587. Epub 2005 Mar 1.
To investigate beliefs about medications held by people with rheumatoid arthritis (RA), what factors are related to these specific medication beliefs, and whether these beliefs influence adherence.
The design was a cross-sectional postal questionnaire survey of people with RA. The Beliefs about Medicines Questionnaire was used to assess beliefs about the necessity of medication and concerns about it. Questionnaires were mailed to 600 out-patients with RA.
The response rate was 57.3%. Most (74.3%) respondents agreed or strongly agreed that their arthritis medications are necessary for their health. However, 47.4% were concerned about potential adverse consequences. The overall necessity score (mean 19.2, s.d. 3.13) was higher than the concerns score (mean 15.84, s.d. 3.53; P<0.001). Greater disability was associated with higher necessity scores (r = 0.36; P<0.001). Greater helplessness correlated with higher concerns scores (r = 0.49; P<0.001). There was no association between RA knowledge and beliefs about medications (necessity scale, r = 0.02, P = 0.66; concerns scale, r=-0.08, P = 0.14). Concerns scores for non-adherent participants (mean 17.88, s.d. 3.29) were higher than for the adherent group (mean 15.64, s.d. 3.51; P = 0.002).
Most people with RA have positive beliefs about the necessity of their medication. However, levels of concern are high and associate with helplessness and non-adherence. The Beliefs about Medicines Questionnaire may identify people at risk of poor adherence and provide a focus for patients to discuss their beliefs, providing opportunities to improve adherence.
调查类风湿关节炎（RA）患者对药物的看法、哪些因素与这些特定的药物观念相关，以及这些观念是否会影响用药依从性。
采用横断面邮寄问卷调查RA患者。使用药物信念问卷评估对药物必要性的信念及其相关担忧。问卷被邮寄给600名RA门诊患者。
回复率为57.3%。大多数（74.3%）受访者同意或强烈同意他们的关节炎药物对其健康是必要的。然而，47.4%的人担心潜在的不良后果。总体必要性得分（均值19.2，标准差3.13）高于担忧得分（均值15.84，标准差3.53；P<0.001）。残疾程度越高，必要性得分越高（r = 0.36；P<0.001）。无助感越强，担忧得分越高（r = 0.49；P<0.001）。RA知识与药物信念之间没有关联（必要性量表，r = 0.02，P = 0.66；担忧量表，r = -0.08，P = 0.14）。未坚持用药参与者的担忧得分（均值17.88，标准差3.29）高于坚持用药组（均值15.64，标准差3.51；P = 0.002）。
大多数RA患者对其药物的必要性持积极信念。然而，担忧程度较高，且与无助感和不依从性相关。药物信念问卷可能识别出依从性差风险较高的人群，并为患者讨论其信念提供一个焦点，从而提供改善依从性的机会。
