Koarada Syuichi, Ide Masaru, Haruta Yoshio, Tada Yoshifumi, Ushiyama Osamu, Morito Fumitaka, Ohta Akihide, Nagasawa Kohei
Division of Rheumatology, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan.
J Rheumatol. 2005 Mar;32(3):562-4.
B cells lacking RP105 molecule, a member of the Toll-like receptor family, were increased in the peripheral blood of 2 patients with antinuclear antibody (ANA) negative systemic lupus erythematosus (SLE). The increased proportion of RP105-lacking B cells was associated with disease activity in patients with ANA-negative SLE. When there are no significant serological markers for SLE, analysis of expression of RP105 may be helpful in evaluation of activity in ANA-negative SLE. We describe a new approach, using phenotyping of B cells, to evaluate activity of ANA-negative SLE.
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