O'Connell M E, Tuokko H, Graves R E, Kadlec H
Department of Psychology, University of Victoria, Victoria, British Columbia, Canada.
J Clin Exp Neuropsychol. 2004 Oct;26(7):970-80. doi: 10.1080/113803390490510998.
We investigated the effects of correcting for demographic biases on the sensitivity and specificity of the Modified Mini Mental Status Exam (3MS) using a sample of English-speaking older adults (N=8901) from the Canadian Studies of Health and Aging. The sensitivity and specificity of the original 3MS were compared to the 3MS regression-adjusted for the influence of demographic variables and then to 3MS percentiles based on published normative data with age and education corrected cutoff scores. According to receiver operating characteristic curve analyses, the regression-adjusted 3MS was no more accurate than the original 3MS when screening for dementia, and it was less accurate when screening for cognitive impairment. The use of 3MS percentiles based on normative data with age and education corrected cut-off points were less accurate than the original 3MS when screening for both cognitive impairment and when screening for dementia.
我们使用来自加拿大健康与老龄化研究的讲英语的老年人样本(N = 8901),研究了校正人口统计学偏差对改良简易精神状态检查表(3MS)的敏感性和特异性的影响。将原始3MS的敏感性和特异性与针对人口统计学变量影响进行回归调整后的3MS进行比较,然后与基于已发表的规范数据且年龄和教育校正了临界值的3MS百分位数进行比较。根据受试者工作特征曲线分析,在筛查痴呆症时,回归调整后的3MS并不比原始3MS更准确,而在筛查认知障碍时,其准确性更低。当筛查认知障碍和筛查痴呆症时,使用基于年龄和教育校正了临界点的规范数据的3MS百分位数比原始3MS的准确性更低。