Ensari Arzu, Savas Berna, Okcu Heper Aylin, Kuzu Isinsu, Idilman Ramazan
Department of Pathology, Medical School, Ankara University , Ankara, Turkey.
Virchows Arch. 2005 Apr;446(4):463-6. doi: 10.1007/s00428-005-1215-5. Epub 2005 Mar 3.
Helicobacter pylori (H. pylori) is a "slow" bacterial pathogen, which induces several gastroduodenal diseases. Varying degrees of inflammation can be present in the gastric mucosa of patients infected with H. pylori. The case presented here is a male patient suffering from dyspepsia and nausea. His upper gastrointestinal endoscopy revealed pan gastritis. Histological examination of multiple gastric biopsies taken from the body and antrum showed a rare morphological expression of H. pylori gastritis characterized by diffuse plasma cell infiltration with extensive Russell body formation. Diffuse infiltration of plasma cells with Russell bodies in gastric mucosa can cause difficulties in differentiation from neoplastic processes. However, immunohistochemically, the infiltrating cells in the gastric mucosa stained negatively with cytokeratins while they expressed both kappa and lambda light chains showing their polyclonal nature. The presence of diffuse plasma cells with Russell bodies in the gastric mucosa may represent a different presentation of H. pylori gastritis. There are only two case reports of similar presentation and both have been called "Russell body gastritis".
幽门螺杆菌（H. pylori）是一种“缓慢”的细菌病原体，可引发多种胃十二指肠疾病。感染幽门螺杆菌的患者胃黏膜中可出现不同程度的炎症。此处呈现的病例是一名患有消化不良和恶心的男性患者。他的上消化道内镜检查显示为全胃炎。对取自胃体和胃窦的多个胃活检组织进行组织学检查，发现了一种罕见的幽门螺杆菌胃炎形态学表现，其特征为弥漫性浆细胞浸润并伴有广泛的拉塞尔小体形成。胃黏膜中伴有拉塞尔小体的浆细胞弥漫性浸润可能会导致与肿瘤性病变的鉴别困难。然而，免疫组化显示，胃黏膜中的浸润细胞细胞角蛋白染色为阴性，而它们同时表达κ和λ轻链，表明其多克隆性质。胃黏膜中伴有拉塞尔小体的弥漫性浆细胞的存在可能代表了幽门螺杆菌胃炎的一种不同表现形式。仅有两篇关于类似表现的病例报告，且均被称为“拉塞尔小体胃炎”。
