Paik S, Kim S-H, Kim J-H, Yang W I, Lee Y C
Department of Diagnostic Pathology, Bundang Jesaeng General Hospital, Sungnam-si, Kyungki-do, Korea.
J Clin Pathol. 2006 Dec;59(12):1316-9. doi: 10.1136/jcp.2005.032185.
An unusual and rare gastric mucosal lesion histologically consisting of a localised accumulation of Russell bodies and Russell body-containing plasma cells, the so-called Mott cells, has been recognised only recently and termed as "Russell body gastritis". This lesion, despite its densely monomorphous appearance is easily confirmed to be non-neoplastic by its polyclonal immunoreactive pattern to immunoglobulin light chains. However, the aetiology of Russell body gastritis is controversial and hence the optimal treatment for this disease has not been established. Two cases of Russell body gastritis associated with Helicobacter pylori infection are reported, and the possible role of H pylori infection in the pathogenesis is discussed.
一种组织学上不寻常且罕见的胃黏膜病变，由Russell小体和含Russell小体的浆细胞（即所谓的Mott细胞）局部聚集组成，直到最近才被认识到，并被称为“Russell小体胃炎”。尽管这种病变外观呈密集的单形性，但通过其对免疫球蛋白轻链的多克隆免疫反应模式，很容易确定为非肿瘤性病变。然而，Russell小体胃炎的病因存在争议，因此该病的最佳治疗方法尚未确立。本文报告了两例与幽门螺杆菌感染相关的Russell小体胃炎病例，并讨论了幽门螺杆菌感染在发病机制中的可能作用。
