Caroli E, Salvati M, Roperto R, D'Andrea G, Ferrante L
Department of Neurological Sciences -- Neurosurgery, Policlinico S. Andrea, University of Rome "La Sapienza", Rome, Italy.
Zentralbl Neurochir. 2005 Feb;66(1):39-42. doi: 10.1055/s-2004-832472.
High-dose radiation-induced meningiomas in children are a rare occurrence. We discuss the clinical data and the differences of these rare tumors from those of spontaneous counterpart and radiation-induced meningiomas of the adult population.
We report a case of meningothelial meningioma, which occurred in a 9-year-old boy who underwent radiotherapy for a parieto-occipital cutaneous angioma. In addition, we collected 18 cases of high-dose radiation-induced meningiomas in children from a literature review with Medline.
Radiation-induced meningiomas in children show a female predominance, a short latency period that seems to be related to the age at irradiation, and an aggressive behaviour.
Exposure to the potentially carcinogenic effects of radiotherapy should be reserved only for tumors that demonstrate subsequent progression. A meticulous follow-up of patients treated with radiation therapy is mandatory.
儿童高剂量辐射诱发的脑膜瘤极为罕见。我们讨论这些罕见肿瘤的临床数据，以及它们与成人自发性脑膜瘤和辐射诱发脑膜瘤的差异。
我们报告一例脑膜皮型脑膜瘤，发生于一名9岁男孩，该男孩曾因顶枕部皮肤血管瘤接受放射治疗。此外，我们通过检索医学期刊数据库（Medline）对文献进行综述，收集了18例儿童高剂量辐射诱发脑膜瘤的病例。
儿童辐射诱发的脑膜瘤以女性居多，潜伏期短，这似乎与照射时的年龄有关，且具有侵袭性。
放疗潜在致癌作用的暴露应仅用于有后续进展的肿瘤。对接受放疗的患者进行细致的随访是必不可少的。
