Alsabti E A
Oncology. 1979;36(4):171-5. doi: 10.1159/000225334.
To determine the degree of correlation among the various in vivo and in vitro assays that could be used to assess immunocompetence in bronchogenic carcinoma, the response to common recall skin antigens, primary sensitization to DNCB and lymphocyte function tests based on blastogenic response to mitogens and in mixed lymphocyte culture (MLC) were tested in 48 patients with bronchogenic carcinoma. The values were compared to responses in 94 age-matched healthy control subjects. There were impaired skin tests reactions among squamous cell carcinoma patients, with little impairment of their lymphocyte blastogenesis reactions. Anaplastic carcinoma patients had notable defects in lymphocyte function tests but less impairment of the skin test reactions. These data suggest that the mitogen concanavalin A, phytohemagglutinin, and the MLC are more useful screening assays of in vitro immunocompetence than are the other commonly used mitogens.
为了确定可用于评估支气管源性癌免疫能力的各种体内和体外检测方法之间的相关程度，对48例支气管源性癌患者进行了对常见回忆性皮肤抗原的反应、对二硝基氯苯（DNCB）的初次致敏以及基于对有丝分裂原的增殖反应和混合淋巴细胞培养（MLC）的淋巴细胞功能测试。将这些值与94名年龄匹配的健康对照受试者的反应进行比较。鳞状细胞癌患者的皮肤试验反应受损，但其淋巴细胞增殖反应受损较小。间变性癌患者在淋巴细胞功能测试中有明显缺陷，但皮肤试验反应受损较小。这些数据表明，与其他常用的有丝分裂原相比，有丝分裂原刀豆球蛋白A、植物血凝素和MLC是更有用的体外免疫能力筛选检测方法。
