Kahn R S, Davidson M, Hirschowitz J, Stern R G, Davis B M, Gabriel S, Moore C, Davis K L
Clinical Research Unit, Bronx Veterans Administration, NY 10468.
Psychiatry Res. 1992 Feb;41(2):155-61. doi: 10.1016/0165-1781(92)90107-e.
Plasma growth hormone concentrations were measured at hourly intervals between 10 p.m. and 8 a.m. the next morning in 15 drug-free chronic schizophrenic male inpatients and 14 healthy males. Growth hormone secretion was significantly lower in the patients as compared with the controls. Growth hormone release peaked around 1 a.m. in the controls, but a growth hormone peak was absent in the patient group. Increased dopamine activity, increased serotonin activity, or both could explain the absence of a nocturnal growth hormone surge in the schizophrenic patients.
在晚上10点至次日上午8点期间，每隔一小时测量15名未服用药物的慢性精神分裂症男性住院患者和14名健康男性的血浆生长激素浓度。与对照组相比，患者的生长激素分泌显著降低。对照组的生长激素释放在凌晨1点左右达到峰值，但患者组未出现生长激素峰值。多巴胺活性增加、血清素活性增加或两者兼而有之，可能解释了精神分裂症患者夜间生长激素激增的缺失。
