Rao M L, Gross G, Strebel B, Halaris A, Huber G, Bräunig P, Marler M
Psychiatrische Klinik und Poliklinik, Rheinischen Friedrich-Wilhelms-Universität, Bonn, Germany.
Biol Psychiatry. 1994 Feb 1;35(3):151-63. doi: 10.1016/0006-3223(94)91147-9.
Circadian rhythm abnormalities have been described mostly with respect to manic-depressive illness; little information is available concerning circadian rhythms and schizophrenia or their influence on neuroleptic drugs. We showed previously that the MESOR of dopamine is higher in schizophrenic patients than in healthy subjects and that women who are drug-free schizophrenic have lower prolactin MESORs and lower amplitudes than healthy women. We now report the data of a cosinor analysis of tryptophan, serotonin, melatonin, and pituitary hormones in the blood of 34 healthy subjects, 90 drug-free schizophrenics, and 25 neuroleptic-treated schizophrenic patients. This data indicated a significant phase advance of serum tryptophan, prolactin, and melatonin concentrations, a trend toward a phase advance in serotonin. Thyroid stimulating hormone (TSH), and growth hormone concentrations, and decreases in the TSH MESORs among patients compared to healthy subjects. These results suggest that circadian changes, such as phase advances and alterations in MESOR, are not only present in depression but also in schizophrenia. Although neuroleptic treatment raised the prolactin MESOR and amplitude, it did not elicit any change in circadian rhythmicity among the other parameters.
昼夜节律异常大多是针对躁郁症进行描述的；关于昼夜节律与精神分裂症及其对神经安定药物的影响，目前所知甚少。我们先前表明，精神分裂症患者多巴胺的中值（MESOR）高于健康受试者，且未服用药物的女性精神分裂症患者的催乳素中值和振幅低于健康女性。我们现在报告对34名健康受试者、90名未服用药物的精神分裂症患者和25名接受神经安定药物治疗的精神分裂症患者血液中的色氨酸、血清素、褪黑素和垂体激素进行余弦分析的数据。这些数据表明，血清色氨酸、催乳素和褪黑素浓度显著提前，血清素、促甲状腺激素（TSH）和生长激素浓度有提前的趋势，与健康受试者相比，患者的TSH中值降低。这些结果表明，昼夜节律变化，如相位提前和中值改变，不仅存在于抑郁症中，也存在于精神分裂症中。尽管神经安定药物治疗提高了催乳素的中值和振幅，但在其他参数中并未引起昼夜节律的任何变化。
