Busatto G F, Costa D C, Ell P J, Pilowsky L S, David A S, Kerwin R W
Department of Neuroscience and Psychiatric Genetics, Institute of Psychiatry, London.
Psychol Med. 1994 May;24(2):463-72. doi: 10.1017/s0033291700027434.
Regional cerebral blood flow (rCBF) was investigated in a group of medicated DSM-III-R schizophrenic patients and age, sex and handedness matched normal volunteers using a split-dose 99mTc-HMPAO Single Photon Emission Tomography (SPET) protocol. Measures were taken during the performance of a verbal memory task aimed at activating the left medial temporal lobe, a region repeatedly suggested to be structurally abnormal in schizophrenia. In normal subjects, the performance of the task was associated with significant rCBF increases in the left medial temporal, left inferior frontal and anterior cingulate cortices, and right cerebellum. Despite their significantly poorer performance on the memory task, the degree of medial temporal activation measured in the schizophrenic patients was not significantly different from that found in the control group. This finding suggests that memory deficits in schizophrenia do not necessarily imply failure to activate the left medial temporal lobe as assessed by 99mTc-HMPAO SPET.
采用分剂量99mTc-HMPAO单光子发射断层扫描（SPET）方案，对一组服用药物的DSM-III-R精神分裂症患者以及年龄、性别和利手相匹配的正常志愿者进行了局部脑血流量（rCBF）研究。在执行一项旨在激活左内侧颞叶的言语记忆任务期间进行了测量，左内侧颞叶是一个反复提示在精神分裂症中存在结构异常的区域。在正常受试者中，该任务的执行与左内侧颞叶、左下额叶和前扣带回皮质以及右小脑的rCBF显著增加相关。尽管精神分裂症患者在记忆任务上的表现明显较差，但在精神分裂症患者中测量到的内侧颞叶激活程度与对照组并无显著差异。这一发现表明，精神分裂症中的记忆缺陷并不一定意味着如通过99mTc-HMPAO SPET评估的那样无法激活左内侧颞叶。
