Crawford T J, Puri B K, Nijran K S, Jones B, Kennard C, Lewis S W
Academic Unit of Neurosciences, Charing Cross and Westminster Medical School, London.
Psychol Med. 1996 Mar;26(2):265-77. doi: 10.1017/s0033291700034668.
Recent research has shown that some patients with schizophrenia have a severe impairment in the suppression of reflexive saccadic eye movements in the ANTI-saccade task. This saccadic distractibility has previously been found in patients with lesions of dorsolateral prefrontal cortex, implicating an abnormality of prefrontal cortex. The objective of the present study was to determine the contribution of these and other areas to the ANTI-saccadic abnormality in schizophrenia by functional neuroimaging. Using 99mtechnetium-HMPAO high resolution multidetector single-photon emission tomography, regional cerebral blood flow (rCBF) during performance of the ANTI-saccade eye-movement task was compared, by statistical parametric mapping, in ten male schizophrenic patients on stable antipsychotic medication who had a high distractibility error rate on the task, and eight similar patients who had normal distractibility error rates. Compared with the normal error group, the patients with high error rates showed significantly decreased rCBF bilaterally, in the anterior cingulate, insula, and in left striatum. These same patients also had increased perseverative errors on the Wisconsin Card Sort Test.
最近的研究表明，一些精神分裂症患者在反扫视任务中抑制反射性眼球快速运动方面存在严重障碍。此前在背外侧前额叶皮质受损的患者中发现了这种眼球快速运动易分散性，这表明前额叶皮质存在异常。本研究的目的是通过功能神经影像学确定这些区域和其他区域对精神分裂症患者反扫视异常的影响。使用99m锝-HMPAO高分辨率多探测器单光子发射断层扫描，通过统计参数映射，比较了10名服用稳定抗精神病药物且在任务中具有高易分散性错误率的男性精神分裂症患者和8名具有正常易分散性错误率的类似患者在执行反扫视眼球运动任务期间的局部脑血流量（rCBF）。与正常错误组相比，高错误率患者在前扣带回、岛叶和左侧纹状体双侧的rCBF显著降低。这些患者在威斯康星卡片分类测试中也有更多的持续性错误。
