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Novel beta-(imidazol-4-yl)-beta-amino acids: solid-phase synthesis and study of their inhibitory activity against geranylgeranyl protein transferase type I.

作者信息

Saha Ashis K, End David W

机构信息

Janssen Research Foundation, Welsh & McKean Roads, Spring House, PA 19477, USA.

出版信息

Bioorg Med Chem Lett. 2005 Mar 15;15(6):1713-9. doi: 10.1016/j.bmcl.2005.01.042.

DOI:10.1016/j.bmcl.2005.01.042
PMID:15745827
Abstract

Solid-phase synthesis of imidazolyl-beta-amino acid derivatives is described. Several analogs demonstrated moderate inhibition of geranylgeranyl protein transferase type I (GGPT I).

摘要

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