School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, China.
J Fluoresc. 2013 Sep;23(5):1099-105. doi: 10.1007/s10895-013-1239-1. Epub 2013 Jun 9.
A series of novel stilbene-triazine derivatives containing amino acid groups were synthesized and screened to evaluate their cytotoxicity. The UV absorptions of the derivatives were in the range of 240-450 nm. The absorption peaks of the cis-isomers and trans-isomers were in 281-291 nm and 353-361 nm, respectively. Their fluorescence emission peaks of the derivatives were located in the range of 400-650 nm. The whiteness data indicated that all the stilbene-triazine-amino acid derivatives showed excellent whitening effect on cotton fiber compared to untreated cotton. The preliminary cytotoxicity of these derivatives on a mouse fibroblast cell line (L-929 cells) was also investigated. The results showed that the compounds (7a-h) were nontoxic to L-929 cells as fluorescent whitening agents.
一系列含氨基酸基团的新型二苯乙烯-三嗪衍生物被合成并进行了细胞毒性筛选评估。这些衍生物的紫外吸收范围在 240-450nm 之间。顺式异构体和反式异构体的吸收峰分别在 281-291nm 和 353-361nm。它们的荧光发射峰位于 400-650nm 范围内。白度数据表明，与未经处理的棉相比，所有二苯乙烯-三嗪-氨基酸衍生物均显示出优异的棉纤维增白效果。这些衍生物对小鼠成纤维细胞系（L-929 细胞）的初步细胞毒性也进行了研究。结果表明，作为荧光增白剂，化合物（7a-h）对 L-929 细胞无毒。
