Bradley Linda M, Haynes Laura, Swain Susan L
Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA.
Trends Immunol. 2005 Mar;26(3):172-6. doi: 10.1016/j.it.2005.01.004.
During an immune response, peripheral T-cell populations expand and then contract as the response subsides, thus maintaining a fairly constant number of CD4 and CD8 T cells throughout the life of the individual. The important factors that control this homeostasis are now beginning to be understood. Interleukin-7 (IL-7) has emerged as a central regulator of the survival and homeostasis of CD4 and CD8 T cells. Both naive and memory T-cell populations are highly dependent on the presence of IL-7 for their persistence and survival. In this Review, we discuss the role of IL-7 in the survival and homeostasis of naive and memory T cells and how that role is regulated by other factors.
在免疫反应过程中，外周T细胞群体随着反应消退而先扩增后收缩，从而在个体的整个生命过程中维持CD4和CD8 T细胞数量相对恒定。目前人们开始了解控制这种稳态的重要因素。白细胞介素-7（IL-7）已成为CD4和CD8 T细胞存活及稳态的核心调节因子。初始T细胞群体和记忆T细胞群体的持续存在和存活都高度依赖IL-7的存在。在本综述中，我们讨论IL-7在初始T细胞和记忆T细胞存活及稳态中的作用，以及该作用是如何受到其他因素调节的。
