Seddon Benedict, Tomlinson Peter, Zamoyska Rose
Division of Molecular Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
Nat Immunol. 2003 Jul;4(7):680-6. doi: 10.1038/ni946. Epub 2003 Jun 15.
Immunological memory depends on the long-term maintenance of memory T cells. Although the factors that maintain CD8 T cell memory are well understood, those responsible for CD4 memory are not well defined. We have shown here that interleukin 7 (IL-7) was an important survival factor for CD4 memory T cells that together with T cell receptor (TCR) signals regulated homeostasis of the CD4 memory population in lymphopenic conditions and in the intact immune system. Thus, IL-7 contributes to the maintenance of all naive and memory T cell subsets, and therefore controls the overall size of the T cell pool.
免疫记忆依赖于记忆性T细胞的长期维持。尽管维持CD8 T细胞记忆的因素已为人熟知，但负责CD4记忆的因素尚不明确。我们在此表明，白细胞介素7（IL-7）是CD4记忆性T细胞的重要存活因子，它与T细胞受体（TCR）信号共同调节淋巴细胞减少条件下以及完整免疫系统中CD4记忆群体的稳态。因此，IL-7有助于维持所有幼稚和记忆性T细胞亚群，从而控制T细胞库的整体规模。
