Kim S G, Kim H Y, Seo J A, Lee K W, Oh J H, Kim N H, Choi K M, Baik S H, Choi D S
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, South Korea.
Eur J Endocrinol. 2005 Feb;152(2):225-31. doi: 10.1530/eje.1.01842.
We aimed to investigate the relationship between nonalcoholic fatty liver disease (NAFLD), serum adiponectin concentration and brachial-ankle pulse wave velocity (baPWV) as a risk marker for atherosclerosis.
A total of 213 nonalcoholic subjects (67 males, 146 females) participated in this study. Division of subjects into the NAFLD group or the normal group was based on the existence of fatty liver detected by sonography.
Serum adiponectin levels in the NAFLD group were significantly lower than those in the normal group. After adjusting for age, body-mass index (BMI) and the homeostasis model of assessment (HOMA), there was a significant negative correlation between NAFLD and serum adiponectin level only in females (r = -0.22, P = 0.008). Multiple logistic regression analysis showed a tendency of inverse correlation between NAFLD and serum adiponectin level in females (P = 0.055). After adjustment for age, BMI and HOMA value, serum adiponectin levels were inversely correlated with serum alanine aminotransferase (ALT) and gamma-glutamyltranspeptidase (GGT) levels (r = -0.199 (P = 0.004) and r = -0.282 (P < 0.001)). On the other hand, baPWV in the NAFLD group was also significantly higher than that in the normal group in females (P = 0.005). Individual levels of serum ALT, aspatate aminotransferase (AST), alkaline phosphatase (ALP) and GGT were positively correlated with baPWV after adjusting for age, sex, BMI, HOMA and systolic blood pressure (P < 0.05).
Serum adiponectin level and baPWV were significantly associated with NAFLD and various liver enzymes, especially in females.
我们旨在研究非酒精性脂肪性肝病（NAFLD）、血清脂联素浓度与作为动脉粥样硬化风险标志物的臂踝脉搏波速度（baPWV）之间的关系。
共有213名非酒精性受试者（67名男性，146名女性）参与了本研究。根据超声检查发现的脂肪肝情况将受试者分为NAFLD组或正常组。
NAFLD组的血清脂联素水平显著低于正常组。在调整年龄、体重指数（BMI）和稳态模型评估（HOMA）后，仅在女性中，NAFLD与血清脂联素水平之间存在显著负相关（r = -0.22，P = 0.008）。多因素logistic回归分析显示女性中NAFLD与血清脂联素水平呈负相关趋势（P = 0.055）。在调整年龄、BMI和HOMA值后，血清脂联素水平与血清丙氨酸氨基转移酶（ALT）和γ-谷氨酰转肽酶（GGT）水平呈负相关（r = -0.199（P = 0.004）和r = -0.282（P < 0.001））。另一方面，NAFLD组女性的baPWV也显著高于正常组（P = 0.005）。在调整年龄、性别BMI、HOMA和收缩压后，血清ALT、天冬氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）和GGT的个体水平与baPWV呈正相关（P < 0.05）。
血清脂联素水平和baPWV与NAFLD及各种肝酶显著相关，尤其是在女性中。
