Seo J A, Kim N H, Park S Y, Kim H Y, Ryu O H, Lee K W, Lee J, Kim D L, Choi K M, Baik S H, Choi D S, Kim S G
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea.
Clin Endocrinol (Oxf). 2008 Apr;68(4):555-60. doi: 10.1111/j.1365-2265.2007.03072.x. Epub 2007 Oct 17.
Retinol-binding protein 4 (RBP4) is a recently identified adipokine that is elevated in the serum in several insulin-resistant states. We investigated the relationship between non-alcoholic fatty liver disease (NAFLD) and serum RBP4 in nondiabetic adults.
One hundred and fifty-nine nondiabetic, non-alcoholic subjects (95 males and 64 females) participated in this study. Division of subjects into a NAFLD group (n = 73; 45 males and 28 females) or a normal group (n = 86; 50 males and 36 females) was based on the presence of fatty liver disease determined by sonography.
Serum RBP4 levels in the NAFLD group were significantly higher than those in the normal group (62.8 +/- 16.0 mg/l vs. 51.7 +/- 14.6 mg/l, P < 0.0001). Multiple logistic regression analysis revealed that the RBP4 level was an independent factor associated with NAFLD (P = 0.0042). In addition, serum RBP4 levels were positively correlated with serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltranspeptidase (GGT) levels. The significant association between serum RBP4 and GGT levels remained even after adjusting for age, gender, body mass index, the homeostasis model of assessment (HOMA) value and the presence of NAFLD (r = 0.3097, P = 0.0002).
Serum RBP4 levels are significantly associated with NAFLD and liver enzymes.
视黄醇结合蛋白4（RBP4）是一种最近发现的脂肪因子，在几种胰岛素抵抗状态下血清中水平会升高。我们研究了非糖尿病成年人中非酒精性脂肪性肝病（NAFLD）与血清RBP4之间的关系。
159名非糖尿病、非酒精性受试者（95名男性和64名女性）参与了本研究。根据超声检查确定的脂肪肝疾病情况，将受试者分为NAFLD组（n = 73；45名男性和28名女性）或正常组（n = 86；50名男性和36名女性）。
NAFLD组的血清RBP4水平显著高于正常组（62.8±16.0 mg/l对51.7±14.6 mg/l，P < 0.0001）。多因素逻辑回归分析显示，RBP4水平是与NAFLD相关的独立因素（P = 0.0042）。此外，血清RBP4水平与血清丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）和γ-谷氨酰转肽酶（GGT）水平呈正相关。即使在调整了年龄、性别、体重指数、稳态模型评估（HOMA）值和NAFLD的存在后，血清RBP4与GGT水平之间的显著关联仍然存在（r = 0.3097，P = 0.0002）。
血清RBP4水平与NAFLD和肝酶显著相关。
