[口腔鳞状细胞癌中细胞外信号调节蛋白激酶与淋巴结转移的研究]
[Investigation of extracellular signal-regulated protein kinase and lymphnode metastasis in oral squamous cell carcinoma].
作者信息
Wang Qiu-Xu, Shen Lei, Sun Chang-Fu
机构信息
Department of Oral and Maxillofacial Surgery, 2nd Hospital of China Medical University. Shenyang 110004, Liaoning Province, China.
出版信息
Shanghai Kou Qiang Yi Xue. 2005 Feb;14(1):18-20.
PURPOSE
To study the relationship between the expression of extracellular signal-regulated protein kinase (ERK) and the differentiation degree and lymphnode metastasis in oral squamous cell carcinoma.
METHODS
Immunohistochemical staining was used in 41 cases of OSCC to investigate the expression of ERK protein. Student's t test were used for statistical analysis.
RESULTS
A significant relationship was observed between the expression intensity of ERK protein and clinicopathological features of OSCC (P<0.01). A significant relationship was observed between the expression intensity of ERK protein and lymph node metastasis of OSCC(P<0.05). No correlation between the expression intensity of ERK protein and cell differentiation degree of OSCC (P>0.05) was found.
CONCLUSIONS
Activation of ERK may play a strong role in the development of OSCC. Intensive expression of ERK protein may be an important presage marker in OSCC patients.
目的
研究细胞外信号调节蛋白激酶（ERK）的表达与口腔鳞状细胞癌的分化程度及淋巴结转移之间的关系。
方法
采用免疫组织化学染色法对41例口腔鳞状细胞癌病例进行检测，以研究ERK蛋白的表达情况。采用Student's t检验进行统计学分析。
结果
观察到ERK蛋白的表达强度与口腔鳞状细胞癌的临床病理特征之间存在显著相关性（P<0.01）。观察到ERK蛋白的表达强度与口腔鳞状细胞癌的淋巴结转移之间存在显著相关性（P<0.05）。未发现ERK蛋白的表达强度与口腔鳞状细胞癌的细胞分化程度之间存在相关性（P>0.05）。
结论
ERK的激活可能在口腔鳞状细胞癌的发展中起重要作用。ERK蛋白的高表达可能是口腔鳞状细胞癌患者的一个重要预后指标。
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