Wenger Nanette K
Division of Cardiology, Emory University School of Medicine; Grady Memorial Hospital; Emory Heart and Vascular Center, Atlanta, Georgia, USA.
Pediatr Blood Cancer. 2005 Jun 15;44(7):625-9. doi: 10.1002/pbc.20348.
Coronary heart disease is the leading cause of death among women of older age. Interest emerged as to whether premenopausal endogenous estrogen conferred cardiac protection and whether menopausal hormone therapy might prove beneficial. The results of pivotal clinical trials including the randomized, placebo-controlled hormone trial of the Women's Health Initiative (WHI) and the Heart and Estrogen/progestin Replacement Study (HERS) have led to new Guidelines from the American Heart Association (AHA) that state that hormone therapy should not be initiated or continued for the primary or secondary prevention of cardiovascular disease in menopausal women.
冠心病是老年女性死亡的主要原因。绝经前内源性雌激素是否具有心脏保护作用以及绝经后激素治疗是否有益，这一问题引发了人们的关注。包括女性健康倡议（WHI）的随机、安慰剂对照激素试验以及心脏与雌激素/孕激素替代研究（HERS）在内的关键临床试验结果，促使美国心脏协会（AHA）出台了新的指南，该指南指出，绝经后女性不应为了心血管疾病的一级或二级预防而开始或继续使用激素治疗。
