Trisi Paolo, Keith Daulton J, Rocco Sabina
Biomaterials Clinical Research Association, BioCRA via San Silvestro, 163/3, 65132 Pescara, Italy.
Int J Oral Maxillofac Implants. 2005 Jan-Feb;20(1):124-30.
No consensus exists on the long-term performance of hydroxyapatite (HA) coatings on dental implants. The aim of this study was to evaluate the long-term stability of the HA coating in a human autopsy specimen.
Two mandibular HA-coated implants were retrieved postmortem from a woman after 10 years of functional loading with an implant/tooth-supported fixed partial denture. After ground sectioning, the specimens were histomorphometrically analyzed.
Direct bone-implant contact was found at 78.48% of the implant surface. HA coating disappearance had occurred in a few areas (22.75%), but bone was in direct apposition to the titanium surface. Bone volume measured 27.66%, and expected bone-implant contact was 37.55%. No inflammatory reaction was seen in the supracrestal soft tissues or the bone compartment.
Most of the HA coating was maintained on the implants, and areas lacking HA were directly apposed by bone. This observation suggests that the underlying titanium surface should have a macro-texture to promote the adaptation of bone to the titanium surface in case of HA disappearance, as well as to decrease failure at the HA-titanium interface.
In a patient in whom prosthetic treatment was appropriately performed and proper plaque control was maintained, the HA coating was not damaged and contributed to the success of the implant over 10 years of clinical functioning.
对于牙种植体上羟基磷灰石（HA）涂层的长期性能，目前尚无共识。本研究的目的是评估HA涂层在人体尸检标本中的长期稳定性。
从一名女性患者身上取出两枚下颌HA涂层种植体，该患者使用种植体/牙齿支持的固定局部义齿进行了10年的功能负载。经过磨片切片后，对标本进行组织形态计量学分析。
在种植体表面的78.48%处发现了直接的骨-种植体接触。在一些区域（22.75%）出现了HA涂层消失的情况，但骨直接与钛表面贴合。骨体积测量为27.66%，预期的骨-种植体接触为37.55%。在龈上软组织或骨腔中未观察到炎症反应。
大部分HA涂层保留在种植体上，缺乏HA的区域直接与骨贴合。这一观察结果表明，在HA消失的情况下，底层钛表面应具有宏观纹理，以促进骨与钛表面的适配，并减少HA-钛界面处的失败。
在进行了适当的修复治疗并保持了良好的菌斑控制的患者中，HA涂层在10年的临床功能中未受到损害，并有助于种植体的成功。
