Schliephake Henning, Scharnweber Dieter, Roesseler Sophie, Dard Michel, Sewing Andreas, Aref Arash
Department of Oral and Maxillofacial Surgery, George-Augusta-University, Göttingen, Germany.
Int J Oral Maxillofac Implants. 2006 Sep-Oct;21(5):738-46.
The aim of the present study was to test the hypothesis that calcium phosphate coating of titanium screw-type implants enhances peri-implant bone formation in the jaw.
Ten adult female foxhounds received experimental titanium screw-type implants in the mandible 3 months after removal of all premolar teeth. Four types of implants were evaluated in each animal: implants with machined titanium surface (the control group), implants coated with collagen I (the collagen-only group), implants with a composite coating of calcium phosphate and mineralized collagen I (the composite group), and implants with calcium phosphate (hydroxyapatite [HA]) coating (the HA-only group). Peri-implant bone regeneration was assessed histomorphometrically after 1 and 3 months in 5 dogs each by measuring bone-implant contact (BIC) and the volume density of the newly formed peri-implant bone (BVD).
After 1 month, BIC was significantly enhanced only in the group of implants with composite coating of calcium phosphate and mineralized collagen (P = .038). Volume density of the newly formed peri-implant bone was significantly higher in all coated implants after 1 month. No significant difference from baseline was found in BIC for the collagen-only and HA-only groups, but BVD was significantly higher in implants with composite coating (P = .041). After 3 months, BIC and BVD were significantly higher in all coated implants than in the controls with machined surfaces.
It was concluded that composite coating of dental screw-type implant surfaces using calcium phosphate and collagen can enhance BIC and peri-implant bone formation.
本研究的目的是验证以下假设，即钛制螺旋型种植体的磷酸钙涂层可增强颌骨种植体周围的骨形成。
10只成年雌性猎狐犬在拔除所有前磨牙3个月后，于下颌植入实验性钛制螺旋型种植体。每只动物评估四种类型的种植体：机械加工钛表面的种植体（对照组）、涂有I型胶原蛋白的种植体（仅胶原蛋白组）、磷酸钙与矿化I型胶原蛋白复合涂层的种植体（复合组）以及涂有磷酸钙（羟基磷灰石[HA]）涂层的种植体（仅HA组）。分别在1个月和3个月后，通过测量骨-种植体接触（BIC）和新形成的种植体周围骨的体积密度（BVD），对5只犬的种植体周围骨再生情况进行组织形态计量学评估。
1个月后，仅磷酸钙与矿化胶原蛋白复合涂层的种植体组的BIC显著增强（P = 0.038）。1个月后，所有涂层种植体新形成的种植体周围骨的体积密度均显著更高。仅胶原蛋白组和仅HA组的BIC与基线相比无显著差异，但复合涂层种植体的BVD显著更高（P = 0.041）。3个月后，所有涂层种植体的BIC和BVD均显著高于机械加工表面的对照组。
得出的结论是，使用磷酸钙和胶原蛋白对牙用螺旋型种植体表面进行复合涂层可增强BIC和种植体周围骨形成。
