阿拉伯叙利亚共和国的内脏利什曼病：使用rK39进行早期检测

Visceral leishmaniasis in the Syrian Arab Republic: early detection using rK39.

作者信息

Al-Nahhas S, Shabaan M, Hammoud L, Al-Taweel A, Al-Jorf S

机构信息

Department of Biology, Faculty of Science, University of Damascus, Damascus, Syrian Arab Republic.

出版信息

East Mediterr Health J. 2003 Jul;9(4):856-62.

PMID:15748082

Abstract

Leishmaniasis causes significant morbidity and mortality in areas where it is endemic. A seroprevalence survey was conducted in 2 endemic villages in Daraa, Syrian Arab Republic, where 80 out of 345 children (23.2%) tested positive for visceral leishmaniasis (VL) using rK39 dipstick test. Only 10 cases were symptomatic (12.5%), and 27.5% were positive by ELISA test. All the sera (N = 138) obtained from the control village were negative. Of the rK39 initially positive cases, 52 had seroconverted to negative 9 months later, 55 remained ELISA negative, and none developed the full-blown disease. Being faster and less expensive than other diagnostic tests, rK39 is a rapid, sensitive and specific diagnostic tool for symptomatic cases of VL in remote areas with poor accessibility to health services.

摘要

利什曼病在其流行地区导致了显著的发病率和死亡率。在阿拉伯叙利亚共和国德拉省的两个流行村庄进行了一项血清流行率调查，在345名儿童中，有80名（23.2%）使用rK39试纸条检测内脏利什曼病（VL）呈阳性。只有10例有症状（12.5%），ELISA检测呈阳性的比例为27.5%。从对照村庄获得的所有血清（N = 138）均为阴性。在最初rK39呈阳性的病例中，52例在9个月后血清转化为阴性，55例ELISA仍为阴性，且无一例发展为典型疾病。rK39比其他诊断测试更快且成本更低，是在医疗服务可及性差的偏远地区对有症状的VL病例进行快速、灵敏且特异的诊断工具。