Scalzo Anthony A, Manzur Mitali, Forbes Catherine A, Brown Michael G, Shellam Geoffrey R
Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Nedlands, Australia.
Immunol Cell Biol. 2005 Apr;83(2):144-9. doi: 10.1111/j.1440-1711.2005.01311.x.
The NK gene complex (NKC) on mouse chromosome 6 encodes receptors that are expressed on NK cells, such as Ly49H, and is involved in regulating NK cell control of virus infections, such as murine cytomegalovirus (MCMV). In the present study, we investigated the level of allelic heterogeneity in NKC loci in populations of outbred wild mice. This work revealed extensive levels of heterogeneity within two wild mouse populations. Analysis of MCMV replication in a population of specific pathogen-free outbred wild mice revealed that low viral titres, which are normally associated with the Cmv1(r) allele of the Cmv1 host resistance locus, were not prevalent in the mice tested. Hence, NKC-mediated resistance associated with Cmv1(r)/Ly49H-like effects was rare in this population. Overall, these data indicate that the NKC region is highly polymorphic and thus it is very likely that it confers on mice sufficient variability to cope with infection by a range of pathogens.
小鼠6号染色体上的NK基因复合体（NKC）编码在NK细胞上表达的受体，如Ly49H，并参与调节NK细胞对病毒感染的控制，如鼠巨细胞病毒（MCMV）。在本研究中，我们调查了远交野生小鼠群体中NKC基因座的等位基因异质性水平。这项工作揭示了两个野生小鼠群体中存在广泛的异质性水平。对一群无特定病原体的远交野生小鼠中的MCMV复制进行分析发现，通常与Cmv1宿主抗性基因座的Cmv1(r)等位基因相关的低病毒滴度，在所测试的小鼠中并不普遍。因此，与Cmv1(r)/Ly49H样效应相关的NKC介导的抗性在该群体中很少见。总体而言，这些数据表明NKC区域具有高度多态性，因此它很可能赋予小鼠足够的变异性以应对一系列病原体的感染。
