Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA.
Viruses. 2009 Dec;1(3):460-83. doi: 10.3390/v1030460. Epub 2009 Oct 20.
Host resistance to infection depends on the efficiency with which innate immune responses keep the infectious agent in check. Innate immunity encompasses components with sensing, signaling and effector properties. These elements with non-redundant functions are encoded by a set of host genes, the resistome. Here, we review our findings concerning the resistome. We have screened randomly mutagenized mice for susceptibility to a natural opportunistic pathogen, the mouse cytomegalovirus. We found that some genes with initially no obvious functions in innate immunity may be critical for host survival to infections, falling into a newly defined category of genes of the resistome.
宿主对感染的抵抗力取决于先天免疫反应抑制感染因子的效率。先天免疫包括具有感应、信号转导和效应功能的成分。这些具有非冗余功能的元件由一组宿主基因（抵抗组）编码。在这里，我们回顾了我们关于抵抗组的发现。我们已经筛选了随机诱变的小鼠对一种自然机会性病原体（小鼠巨细胞病毒）的易感性。我们发现，一些最初在先天免疫中没有明显功能的基因可能对宿主的感染生存至关重要，属于新定义的抵抗组基因类别。
