Wee Sue Ann, Possick Paul
Ronald O. Perelman Department of Dermatology, New York University, USA.
Dermatol Online J. 2004 Nov 30;10(3):18.
A 68-year-old woman presented with a 3-year history of asymptomatic, yellow-brown plaques on the lower extremities with trauma-related superficial ulcers. A biopsy specimen was consistent with necrobiosis lipoidica. Necrobiosis lipoidica is a chronic granulomatous dermatitis that is associated with diabetes mellitus; however, its pathogenesis remains unclear. Topical glucocorticoids are first-line therapy; however, no treatment has proven efficacy in double-blind, placebo-controlled studies.
一名68岁女性,下肢出现无症状的黄棕色斑块并伴有与创伤相关的浅表溃疡,病史3年。活检标本符合类脂质渐进性坏死。类脂质渐进性坏死是一种与糖尿病相关的慢性肉芽肿性皮炎;然而,其发病机制仍不清楚。外用糖皮质激素是一线治疗方法;然而,在双盲、安慰剂对照研究中,尚无治疗被证明有效。