Kino Katsuhito, Sugiyama Hiroshi
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Shido, Kagawa 769-2193, Japan.
Mutat Res. 2005 Apr 1;571(1-2):33-42. doi: 10.1016/j.mrfmmm.2004.10.010. Epub 2005 Jan 25.
Many oxidizing agents induce G-C to T-A and G-C to C-G transversions, and the frequency largely depends on the oxidative conditions. Guanine is the most oxidizable base among natural bases. The typical oxidative lesion product 8-oxoguanine (8-oxoG) is responsible for G-C to T-A transversion but not for G-C to C-G transversion, and 8-oxoG is more readily oxidized than guanine because of its lowered ionization potential. Recently, imidazolone (Iz), guanidinohydantoin (Gh) and spiroiminodihydantoin (Sp) have been demonstrated as oxidative lesion products of guanine and 8-oxoG, which could be responsible for G-C to C-G transversions by forming specific base pair formations.
许多氧化剂会诱导鸟嘌呤-胞嘧啶（G-C）到胸腺嘧啶-腺嘌呤（T-A）以及G-C到胞嘧啶-鸟嘌呤（C-G）的颠换，且频率很大程度上取决于氧化条件。鸟嘌呤是天然碱基中最易被氧化的碱基。典型的氧化损伤产物8-氧代鸟嘌呤（8-oxoG）会导致G-C到T-A的颠换，但不会导致G-C到C-G的颠换，并且由于其较低的电离势，8-oxoG比鸟嘌呤更容易被氧化。最近，咪唑酮（Iz）、胍基乙内酰脲（Gh）和螺环亚氨基二氢嘧啶（Sp）已被证明是鸟嘌呤和8-oxoG的氧化损伤产物，它们可能通过形成特定的碱基对而导致G-C到C-G的颠换。
