Witter Kirsti, Lesot Hervé, Peterka Miroslav, Vonesch Jean-Luc, Mísek Ivan, Peterková Renata
Institute of Histology and Embryology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Wien, Austria.
Arch Oral Biol. 2005 Apr;50(4):401-9. doi: 10.1016/j.archoralbio.2004.10.003. Epub 2004 Dec 8.
Odontogenesis in voles is a convenient model to test hypotheses on tooth development generated from investigations in the mouse. Similar to other rodents, the functional dentition of the vole includes a toothless diastema. At its mesial end, a vestigial tooth bud has been found in the upper jaw of vole embryos. The aim of this study was to analyse the developmental dynamics of vestigial tooth structures in the upper diastema of the field vole and to compare it with the situation in the mouse.
The development of odontogenic structures in the upper diastema of the field vole was investigated using serial histological sections and three-dimensional (3D) computer-aided reconstruction.
A transient continuous dental lamina in the upper diastema of the field vole extended mesially to the first molar primordium, but was not continuous with the dental lamina in the incisor region. At its mesial limit, a large vestigial tooth primordium was regularly present. A further distinct vestigial bud was located mesially to the first molar primordium. The segmentation of the dental lamina suggested a potential to give rise to further vestiges in the upper diastema of the vole.
In the prospective diastema of the vole exists as in the mouse a continuous dental lamina. Beside the prominent vestigial tooth bud in the mesial diastema, a further large bud was transiently located in front of the molars. The incorporation of dental epithelium into the first upper molar (M(1)) primordium in the vole differs from that in the mouse.
田鼠的牙发生是一个方便的模型，可用于检验从小鼠研究中得出的牙齿发育假说。与其他啮齿动物类似，田鼠的功能性牙列包括一个无牙的间隙。在其近中端，已在田鼠胚胎的上颌中发现一个退化的牙胚。本研究的目的是分析田鼠上颌间隙中退化牙齿结构的发育动态，并将其与小鼠的情况进行比较。
使用连续组织切片和三维（3D）计算机辅助重建技术研究田鼠上颌间隙中牙源性结构的发育。
田鼠上颌间隙中的一条短暂连续的牙板向近中延伸至第一磨牙原基，但与切牙区域的牙板不连续。在其近中界限处，通常存在一个大的退化牙原基。在第一磨牙原基的近中还存在一个明显的退化牙胚。牙板的分段表明在田鼠上颌间隙中有产生更多退化结构的潜力。
与小鼠一样，在田鼠预期的间隙中存在连续的牙板。除了近中间隙中突出的退化牙胚外，在磨牙前方还短暂存在另一个大的牙胚。田鼠上颌第一磨牙（M(1)）原基中牙上皮的并入与小鼠不同。
