White Madeleine P, Aladangady Narendra, Rolton Hilary A, McColl John H, Beattie Jim
Department of Paediatrics and Neonatalogy, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK.
Early Hum Dev. 2005 Feb;81(2):191-5. doi: 10.1016/j.earlhumdev.2004.07.008. Epub 2004 Oct 22.
(1) To determine a normal range for urinary citrate for term babies. (2) To compare urinary citrate measured in ex preterm babies at term with this normal range. (3) To evaluate whether urinary citrate was related to presence of nephrocalcinosis (NC) and chronic Lung Disease (CLD) in these ex preterm babies.
Urinary citrate was measured in 38 healthy term babies (mean birth weight 3.52 kg, mean gestation 41 weeks) at a mean postnatal age of 3 days (1-5 days) and in 53 ex preterm babies (<32 weeks gestation at birth) at term. These preterm babies were part of a larger study on NC in which two renal ultrasound scans were performed at 1 month and term.
The normal range for urinary citrate in term babies was 0.025-2.97 (mean 1.03) mmol/l and citrate/creatinine ratio 0.0011-0.852 (mean 0.27). In the ex-preterm urinary citrate was not significantly different (mean 1.1 vs. 1.03, p=0.7232) but urine citrate /creatinine ratio was significantly higher (mean 1.27 vs. 0.27, p=0.0005). There was no significant difference in urinary citrate or ratios of citrate/creatinine and calcium/citrate in the 11 (20.7%) with NC or in the 17 (32%) babies with CLD. There was no significant relationship found between duration of TPN and urinary citrate measured at term.
We have determined a normal range for urinary citrate in healthy term babies in the first week of life. The range was very wide. Ex preterm babies had similar values at term and there was no association between urinary citrate and NC or CLD.
（1）确定足月儿尿枸橼酸盐的正常范围。（2）将足月时测量的早产婴儿尿枸橼酸盐与该正常范围进行比较。（3）评估这些早产婴儿的尿枸橼酸盐是否与肾钙质沉着症（NC）和慢性肺病（CLD）的存在有关。
对38名健康足月儿（平均出生体重3.52千克，平均孕周41周）在出生后平均3天（1 - 5天）时测量尿枸橼酸盐，并对53名早产婴儿（出生时孕周<32周）在足月时测量尿枸橼酸盐。这些早产婴儿是一项关于NC的更大规模研究的一部分，在1个月和足月时进行了两次肾脏超声扫描。
足月儿尿枸橼酸盐的正常范围为0.025 - 2.97（平均1.03）毫摩尔/升，枸橼酸盐/肌酐比值为0.0011 - 0.852（平均0.27）。早产婴儿足月时的尿枸橼酸盐无显著差异（平均1.1对1.03，p = 0.7232），但尿枸橼酸盐/肌酐比值显著更高（平均1.27对0.27，p = 0.0005）。11名（20.7%）患有NC或17名（32%）患有CLD的婴儿，其尿枸橼酸盐或枸橼酸盐/肌酐及钙/枸橼酸盐比值无显著差异。未发现全胃肠外营养（TPN）持续时间与足月时测量的尿枸橼酸盐之间存在显著关系。
我们确定了健康足月儿出生后第一周尿枸橼酸盐的正常范围。该范围非常宽。早产婴儿足月时的值相似，且尿枸橼酸盐与NC或CLD之间无关联。
