Murphy J L, Mendoza S A
Department of Pediatrics, UCSD School of Medicine.
Child Nephrol Urol. 1990;10(2):76-80.
Urinary citrate prevents nephrocalcinosis in adults. Premature infants have a high incidence of nephrocalcinosis. We measured urinary citrate (Ucit) and creatinine (Ucre) concentrations in infants with and without lung disease. Ucit was lower in the infants requiring mechanical ventilation than in the controls (mean = 9.7 vs. 15, p = 0.05). Ucit/Ucre ratios were lower in hypercarbic (mean = 0.95 vs. 1.47 in normocarbic, p less than 0.05) and acidotic (mean = 0.57 vs. 1.44 in nonacidotic, p less than 0.004) premature infants. The lowered Ucit of premature infants with lung disease (and acidosis or hypercarbia) may predispose to nephrocalcinosis by increased urinary lithogenesis.
尿柠檬酸可预防成人肾钙质沉着症。早产儿肾钙质沉着症的发病率很高。我们测量了患肺病和未患肺病婴儿的尿柠檬酸（Ucit）和肌酐（Ucre）浓度。需要机械通气的婴儿的尿柠檬酸水平低于对照组（平均值分别为9.7和15，p = 0.05）。高碳酸血症（平均值为0.95，正常碳酸血症为1.47，p < 0.05）和酸中毒（平均值为0.57，非酸中毒为1.44，p < 0.004）的早产儿的尿柠檬酸/肌酐比值较低。患有肺病（以及酸中毒或高碳酸血症）的早产儿尿柠檬酸水平降低，可能会因尿石生成增加而导致肾钙质沉着症。
