Porter J D, Perkin M A, Corbel M J, Farrington C P, Watkins J T, Begg N T
Public Health Laboratory Service, Communicable Disease Surveillance Centre, London, UK.
Vaccine. 1992;10(5):334-6. doi: 10.1016/0264-410x(92)90373-r.
Tetanus immune globulin (TIG) continues to be recommended in persons with tetanus-prone wounds who have incomplete or unknown tetanus immunization status. The aim of this study was to determine whether, following a booster dose of tetanus toxoid in adults who had not been immunized in the previous 10 years, there was an antitoxin response to tetanus toxoid booster within 4 days. Thirty-one adults were investigated, baseline levels for tetanus antitoxin assayed using an ELISA technique, and an injection of adsorbed tetanus toxoid (0.5 ml) given. Blood samples for tetanus antitoxin levels were taken at daily intervals for the 4 days following immunization. Tetanus boosters following the primary course but before the present study did not significantly increase the levels of pre-study tetanus antitoxin and following the study booster there was no difference between the preboost levels and the levels on days 1 to 4. This finding indicates that the present recommendations for the use of TIG in tetanus-prone wounds are appropriate.
对于破伤风易感性伤口且破伤风免疫状态不完全或不明的人群，仍建议使用破伤风免疫球蛋白（TIG）。本研究的目的是确定在过去10年未接种疫苗的成年人中，给予一剂破伤风类毒素加强针后，4天内是否会出现针对破伤风类毒素加强针的抗毒素反应。研究了31名成年人，采用ELISA技术检测破伤风抗毒素的基线水平，并注射吸附破伤风类毒素（0.5毫升）。免疫接种后的4天内每天采集血样检测破伤风抗毒素水平。初次免疫过程后但在本研究之前的破伤风加强针并未显著提高研究前破伤风抗毒素水平，且在研究加强针后，加强前水平与第1至4天的水平之间没有差异。这一发现表明，目前关于在破伤风易感性伤口中使用TIG的建议是合适的。
