Trinca J C
Infect Immun. 1974 Jul;10(1):1-5. doi: 10.1128/iai.10.1.1-5.1974.
A study of the rise and fall in circulating tetanus antitoxin in a group of 15 adults after basic and booster immunization indicates that although individuals vary greatly in their responsiveness to toxoid, the falloff in antitoxin appears to be fractionally constant for each individual, and over periods of 5 to 6 years appears to be the same after successive doses. The low level of antitoxin noted in some individuals after basic immunization with a plain toxoid preparation cannot always be rectified by the use of an adsorbed toxoid as a booster. Results indicate that routine boosters need not be administered more frequently than every 10 to 20 years, provided an adsorbed toxoid has been used to initiate active immunization.
一项针对15名成年人在基础免疫和加强免疫后循环破伤风抗毒素升降情况的研究表明，尽管个体对类毒素的反应性差异很大，但抗毒素的下降对每个个体而言似乎呈一定比例恒定，并且在连续接种后的5至6年期间似乎相同。使用普通类毒素制剂进行基础免疫后，部分个体中抗毒素水平较低，使用吸附类毒素作为加强免疫并不能总是纠正这一情况。结果表明，只要使用吸附类毒素启动主动免疫，常规加强免疫不必比每10至20年更频繁地进行。
