Moriya Fumio, Hashimoto Yoshiaki
Department of Legal Medicine, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku City, Kochi 783-8505, Japan.
Forensic Sci Int. 2005 May 10;149(2-3):167-70. doi: 10.1016/j.forsciint.2004.06.013.
A 35-year-old male was found lying in a prone position in his room. He was in cardiopulmonary arrest on arrival to hospital and was pronounced dead. There was no attempt at resuscitation. No miosis was observed on admission. At post-mortem his stomach contained 170 g greenish liquid with a small amount of shredded tobacco leaves. The serum cholinesterase activities were 47-90 IU (normal range for male: 200-440 IU). GC and GC-MS analyses showed nicotine (21.8 mg), methomyl (304 mg), and triazolam (1.69 mg) in his stomach. He had consumed tobacco leaves, Lannate containing water soluble methomyl (45%), and Halcion tablets containing 0.25 mg triazolam. Methomyl concentrations in blood were 3-8 ng/ml. Substantial amounts of methomyl (2260-2680 ng/ml) were detected in cerebrospinal fluid and vitreous humor. Nicotine concentrations in blood ranged from 222 to 733 ng/ml. A small amount of triazolam was detected only in bile (176 ng/ml) and liver (23 ng/g). The cause of death was respiratory paralysis produced by the additive effects of methomyl and nicotine shortly after consumption.
一名35岁男性被发现俯卧在其房间内。他被送至医院时已处于心肺骤停状态，随后被宣布死亡，未进行复苏尝试。入院时未观察到瞳孔缩小。尸检时，他的胃内有170克绿色液体，伴有少量碎烟叶。血清胆碱酯酶活性为47 - 90国际单位（男性正常范围：200 - 440国际单位）。气相色谱（GC）和气相色谱 - 质谱联用（GC - MS）分析显示其胃内含有尼古丁（21.8毫克）、灭多威（304毫克）和三唑仑（1.69毫克）。他曾食用过烟叶、含45%水溶性灭多威的万灵（Lannate）以及含0.25毫克三唑仑的海乐神（Halcion）片剂。血液中灭多威浓度为3 - 8纳克/毫升。脑脊液和玻璃体液中检测到大量灭多威（2260 - 2680纳克/毫升）。血液中尼古丁浓度在222至733纳克/毫升之间。仅在胆汁（176纳克/毫升）和肝脏（23纳克/克）中检测到少量三唑仑。死因是食用后不久灭多威和尼古丁的相加作用导致的呼吸麻痹。
