Yang Rong-Sen, Chen Yin-Zing, Huang Tsang-Hai, Tang Chih-Hsin, Fu Wen-Mei, Lu Bin-Yu, Lin Win-Li
Department of Orthopaedics, National Taiwan University, Taipei, Taiwan.
Ultrasound Med Biol. 2005 Mar;31(3):431-7. doi: 10.1016/j.ultrasmedbio.2004.11.010.
The purpose of this study was to investigate the therapeutic effects of low-intensity ultrasound (US) on the sciatic-neurectomy-induced bone mass decrement in growing rats. A total of 20 male Sprague-Dawley rats (166.7+/-11.3 g) underwent right leg sciatic neurectomy. They were randomly assigned into two groups, US treatment group (UST) and control group (CON). The rats receiving US treatment were treated with a 125 mW/cm2 continuous low-intensity US stimulation for 15 min/day on the lateral site of the right leg. The control rats did not receive any US treatment. All the animals were euthanized after 4-week US treatment. Both the original data and bilateral difference ratio of femur or tibia weight, histomorphometry data and bone densitometry data showed that the sciatic neurectomy obviously reduced bone mass in the operated limbs of both groups. However, the continuous low-intensity US treatment did not ameliorate the neurectomy-induced loss of bone mass. Thus, the low-intensity US generated micromechanical strains might not induce enough bone formation activity to reverse the bone loss in this model of intact bones.
本研究旨在探讨低强度超声（US）对生长中大鼠坐骨神经切断术所致骨量减少的治疗效果。总共20只雄性斯普拉格-道利大鼠（166.7±11.3 g）接受了右下肢坐骨神经切断术。它们被随机分为两组，即超声治疗组（UST）和对照组（CON）。接受超声治疗的大鼠在右下肢外侧部位接受125 mW/cm2的连续低强度超声刺激，每天15分钟。对照大鼠未接受任何超声治疗。在超声治疗4周后，所有动物均被安乐死。股骨或胫骨重量的原始数据和双侧差异率、组织形态计量学数据以及骨密度测量数据均显示，坐骨神经切断术明显降低了两组手术肢体的骨量。然而，连续低强度超声治疗并未改善神经切断术所致的骨量丢失。因此，低强度超声产生的微机械应变可能无法诱导足够的骨形成活性来逆转该完整骨模型中的骨质流失。
