Uddin Sardar M Z, Komatsu David E, Motyka Thomas, Petterson Stephanie
Department of Orthopaedics and Rehabilitation, Stony Brook University, Stony Brook, NY 11794, USA.
Department of Osteopathic Manipulative Medicine, Campbell University, Buies Creek, NC 27506, USA.
J Clin Med. 2021 Jun 18;10(12):2698. doi: 10.3390/jcm10122698.
Therapeutic ultrasound has been studied for over seven decades for different medical applications. The versatility of ultrasound applications are highly dependent on the frequency, intensity, duration, duty cycle, power, wavelength, and form. In this review article, we will focus on low-intensity continuous ultrasound (LICUS). LICUS has been well-studied for numerous clinical disorders, including tissue regeneration, pain management, neuromodulation, thrombosis, and cancer treatment. PubMed and Google Scholar databases were used to conduct a comprehensive review of all research studying the application of LICUS in pre-clinical and clinical studies. The review includes articles that specify intensity and duty cycle (continuous). Any studies that did not identify these parameters or used high-intensity and pulsed ultrasound were not included in the review. The literature review shows the vast implication of LICUS in many medical fields at the pre-clinical and clinical levels. Its applications depend on variables such as frequency, intensity, duration, and type of medical disorder. Overall, these studies show that LICUS has significant promise, but conflicting data remain regarding the parameters used, and further studies are required to fully realize the potential benefits of LICUS.
七十多年来，人们一直在研究治疗性超声在不同医学领域的应用。超声应用的多样性高度依赖于频率、强度、持续时间、占空比、功率、波长和形式。在这篇综述文章中，我们将聚焦于低强度连续超声（LICUS）。LICUS已针对多种临床病症进行了充分研究，包括组织再生、疼痛管理、神经调节、血栓形成和癌症治疗。我们使用PubMed和谷歌学术数据库对所有研究LICUS在临床前和临床研究中应用的文献进行了全面综述。该综述涵盖了明确强度和占空比（连续）的文章。任何未明确这些参数或使用高强度和脉冲超声的研究均未纳入该综述。文献综述表明，LICUS在临床前和临床水平的许多医学领域都有广泛应用。其应用取决于频率、强度、持续时间和医学病症类型等变量。总体而言，这些研究表明LICUS具有巨大潜力，但关于所使用的参数仍存在相互矛盾的数据，需要进一步研究以充分实现LICUS的潜在益处。
