一例结节病伴下颌牙龈鳞状细胞癌。

A case of sarcoidosis accompanying squamous cell carcinoma in the mandibular gingiva.

作者信息

Hanibuchi Masaki, Matsumori Yuka, Nishioka Yasuhiko, Sone Saburo

机构信息

Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.

出版信息

J Med Invest. 2005 Feb;52(1-2):118-21. doi: 10.2152/jmi.52.118.

DOI:10.2152/jmi.52.118

PMID:15751283

Abstract

A 51-year-old man with a history of gingival cancer two years previously was referred to our hospital for further examination of chest abnormal shadow. Bilateral hilar and mediastinal lymphadenopathy, diffuse small nodular opacities and pleural nodules were observed in chest high resolution CT. Serum angiotensin converting enzyme and lysozyme were elevated. Transbronchial lung biopsy specimens demonstrated non-caseous granuloma. CD4-positive lymphocytes were increased in broncho-alveolar lavage (CD4/CD8 ratio 5.47). The patient was diagnosed as having sarcoidosis. Radiological findings were improved and serum angiotensin converting enzyme level was decreased to within the normal range by corticosteroid therapy (prednisolone 30 mg/day). This is the first report of sarcoidosis accompanying the gingival cancer.

摘要

一名51岁男性，两年前有牙龈癌病史，因胸部异常阴影进一步检查而转诊至我院。胸部高分辨率CT显示双侧肺门及纵隔淋巴结肿大、弥漫性小结节状阴影及胸膜结节。血清血管紧张素转换酶和溶菌酶升高。经支气管肺活检标本显示为非干酪样肉芽肿。支气管肺泡灌洗中CD4阳性淋巴细胞增多（CD4/CD8比值为5.47）。该患者被诊断为结节病。经皮质类固醇治疗（泼尼松龙30mg/天）后，影像学表现改善，血清血管紧张素转换酶水平降至正常范围。这是首例伴有牙龈癌的结节病报告。