Breslau N, Davis G C
Department of Psychiatry, Henry Ford Hospital, Detroit, MI 48202-2689.
Am J Psychiatry. 1992 May;149(5):671-5. doi: 10.1176/ajp.149.5.671.
Despite progress in epidemiologic research on posttraumatic stress disorder (PTSD), little is known about factors that distinguish chronic from nonchronic PTSD. In a previous report, the authors identified a set of personal predispositions associated with PTSD following traumatic events in a general population sample of young adults. The purpose of this analysis was to identify characteristics of chronic PTSD and examine whether any of the suspected risk factors for PTSD was associated specifically with chronic PTSD.
A random sample of 1,007 21- to 30-year-old members of a large health maintenance organization in the Detroit area was interviewed, using the National Institute of Mental Health Diagnostic Interview Schedule (DIS), revised for DSM-III-R. The analysis was performed on data from 394 respondents who reported traumatic events, of whom 93 met criteria for PTSD. Chronic PTSD was defined as duration of symptoms for 1 year or more.
Persons with chronic PTSD (N = 53) had, on the average, a significantly higher total number of PTSD symptoms and higher rates of overreactivity to stimuli that symbolized the stressor and interpersonal numbing than persons with nonchronic PTSD. The rates of one or more additional anxiety or affective disorders and a variety of medical conditions were higher in persons with chronic than nonchronic PTSD. Family history of antisocial behavior and female sex were associated specifically with chronic PTSD.
The findings suggest that chronic PTSD may be associated with specific risk factors and clinical features. Longitudinal data on the course of PTSD are needed to determine whether the distinct features and the medical and psychiatric histories of persons with chronic PTSD are complications attendant on a chronic course or coexisting disturbances that inhibit recovery.
尽管创伤后应激障碍(PTSD)的流行病学研究取得了进展,但对于区分慢性PTSD与非慢性PTSD的因素仍知之甚少。在之前的一份报告中,作者在一个年轻成年人的普通人群样本中确定了一组与创伤事件后PTSD相关的个人易感性因素。本分析的目的是确定慢性PTSD的特征,并检查PTSD的任何疑似风险因素是否与慢性PTSD有特定关联。
使用为DSM-III-R修订的美国国立精神卫生研究所诊断访谈表(DIS),对底特律地区一个大型健康维护组织的1007名21至30岁成员进行随机抽样访谈。对394名报告有创伤事件的受访者的数据进行分析,其中93人符合PTSD标准。慢性PTSD定义为症状持续时间达1年或更长时间。
与非慢性PTSD患者相比,慢性PTSD患者(N = 53)平均PTSD症状总数显著更高,对象征应激源的刺激反应过度和人际情感麻木的发生率更高。慢性PTSD患者中一种或多种额外焦虑或情感障碍以及多种躯体疾病的发生率高于非慢性PTSD患者。反社会行为家族史和女性性别与慢性PTSD有特定关联。
研究结果表明,慢性PTSD可能与特定的风险因素和临床特征相关。需要关于PTSD病程的纵向数据来确定慢性PTSD患者的独特特征以及医学和精神病史是慢性病程伴随的并发症还是抑制康复的共存障碍。