来自拟大戟的镇痛二萜。

Antinociceptive diterpene from Euphorbia decipiens.

作者信息

Ahmad Viqar Uddin, Hussain Hidayat, Bukhari Ishfaq A, Hussain Javid, Jassbi Amir Reza, Dar Ahsana

机构信息

HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.

出版信息

Fitoterapia. 2005 Mar;76(2):230-2. doi: 10.1016/j.fitote.2004.12.014.

DOI:10.1016/j.fitote.2004.12.014

PMID:15752637

Abstract

One myrsinol-type diterpene ester (1) isolated from Euphorbia decipiens was evaluated for analgesic activity in the acetic acid induced writhing test in mice. Different dose (5-20 mg/kg i.p.) of the compound showed significant antinociceptive activity, which was comparable to standard analgesic drugs, aspirin and ibuprofen (100 mg/kg i.p.).

摘要

从大戟属植物（Euphorbia decipiens）中分离出的一种半日花烷型二萜酯（1），在小鼠醋酸诱导扭体试验中对其镇痛活性进行了评估。该化合物不同剂量（腹腔注射5-20毫克/千克）显示出显著的抗伤害感受活性，与标准镇痛药阿司匹林和布洛芬（腹腔注射100毫克/千克）相当。