皱叶香科科精油对小鼠的镇痛作用及急性毒性
Antinociceptive effect and acute toxicity of the essential oil of Hyptis fruticosa in mice.
作者信息
Menezes Igor A C, Marques Maxsuel S, Santos Thiago C, Dias Kellyane S, Silva Aline B L, Mello Iderjane C M, Lisboa Ana C C D, Alves Péricles B, Cavalcanti Sócrates C H, Marçal Rosilene M, Antoniolli Angelo R
机构信息
Physiology Department, Federal University of Sergipe, São Cristovão, Brazil.
出版信息
Fitoterapia. 2007 Apr;78(3):192-5. doi: 10.1016/j.fitote.2006.11.020. Epub 2007 Feb 7.
The essential oil of the Hyptis fruticosa leaves was analyzed by GC/MS and evaluated for antinociceptive property as well as acute toxicity in mice. The essential oil, at doses of 100, 200, and 400 mg/kg (s.c.), produced significant inhibition of acetic acid-induced writhing, but did not manifest a significant effect in hot-plate test. There was no acute toxicity at doses up to 5 g/kg. Bicyclogermacrene, 1,8-cineole, alpha-pinene, and beta-caryophyllene were the major compounds detected in the essential oil.
对皱叶香科叶草叶的精油进行了气相色谱/质谱分析，并评估了其对小鼠的抗伤害感受特性以及急性毒性。该精油以100、200和400毫克/千克（皮下注射）的剂量，对醋酸诱导的扭体反应产生了显著抑制作用，但在热板试验中未表现出显著效果。在高达5克/千克的剂量下没有急性毒性。双环大根香叶烯、1,8-桉叶素、α-蒎烯和β-石竹烯是该精油中检测到的主要化合物。
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