以色列与人类嗜T淋巴细胞病毒1型（HTLV-1）相关的成人T细胞白血病/淋巴瘤：两名罗马尼亚裔患者的报告。

HTLV-1 associated adult T-cell leukemia/lymphoma in Israel: report of two patients of Romanian origin.

作者信息

Shtalrid Mordechai, Shvidel Lev, Korenfeld Roman, Duek Adrian, Landau Zvi, Berrebi Alain

机构信息

Department of Hematology, Kaplan Medical Center, Rehovot, 76100, Israel.

出版信息

Haematologica. 2005 Mar;90(3):ECR13.

PMID:15753054

Abstract

Human T-lymphotropic virus type 1 (HTLV-1) was the first human oncovirus isolated by Gallo et al. in 1980 and established as an etiological agent for adult T-cell leukemia/ lymphoma (ATL). Although more than 15 million individuals are infected by HTLV-1 through the world, the spread of the virus is highly endemic. The HTLV-1 infection is prevailing in southwestern Japan, inter-tropical Africa, Central and South America. In Kyushu district, Japan, the seroprevalence reaches >30% in the adult population. In the US, Europe and the Middle East the HTLV-1 infection is very rare, and cases of ATL have been reported sporadically. We describe here acute ATL in two patients of Jewish- Romanian origin. The epidemiological anamnesis and screening indicate that both patients acquired the HTLV-1 from their mothers leaving in Romania.

摘要

人类嗜T淋巴细胞病毒1型（HTLV-1）是1980年由加洛等人分离出的第一种人类致癌病毒，并被确认为成人T细胞白血病/淋巴瘤（ATL）的病原体。尽管全球有超过1500万人感染HTLV-1，但该病毒的传播具有高度地方性。HTLV-1感染在日本西南部、热带非洲、中美洲和南美洲流行。在日本九州地区，成年人群中的血清阳性率超过30%。在美国、欧洲和中东，HTLV-1感染非常罕见，ATL病例也只是偶尔有报道。我们在此描述两名犹太-罗马尼亚裔患者的急性ATL。流行病学调查和筛查表明，这两名患者均从居住在罗马尼亚的母亲那里感染了HTLV-1。