Kropp P, Linstedt U, Gerber W-D
Institut für Medizinische Psychologie und Soziologie, Campus Kiel des Universitätsklinikums Schleswig-Holstein.
Schmerz. 2005 Nov;19(6):489-92, 494-6. doi: 10.1007/s00482-005-0386-y.
Duration of a migraine disease and hypervigilance are factors which possibly enable the transformation from episodic into chronic migraine. To elucidate this assumption, attentional parameters were measured by recording contingent negative variation (CNV) and correlated with the individual duration of migraine disease.
A total of 28 patients (episodic migraine with or without aura) were compared with 16 healthy controls. CNV analysis included amplitude and habituation calculation. Data were correlated with the individual duration of the migraine disease. The migraine group was divided into two groups based on a median split (short vs long lasting) which were compared by t-tests.
Migraine patients produce higher CNV amplitudes than controls. Moreover, migraineurs showed dishabituation while habituation was seen in controls. There was a Pearson correlation coefficient of r = -0.767 between duration of disease and early component of CNV. Patients with long-lasting disease showed lower dishabituation by a higher intercept than patients with short-lasting disease.
The correlation between duration of disease and attentional parameters and the changing dishabituation can be interpreted as an enhancement in preactivation level in patients with long-lasting migraine. Maybe this change is a prerequisite for transformation into chronic migraine.
偏头痛疾病的持续时间和过度警觉是可能促使发作性偏头痛转变为慢性偏头痛的因素。为了阐明这一假设，通过记录关联性负变（CNV）来测量注意力参数，并将其与偏头痛疾病的个体持续时间相关联。
共将28例患者（有或无先兆的发作性偏头痛）与16名健康对照者进行比较。CNV分析包括幅度和习惯化计算。数据与偏头痛疾病的个体持续时间相关联。根据中位数分割将偏头痛组分为两组（持续时间短与长），通过t检验进行比较。
偏头痛患者产生的CNV幅度高于对照组。此外，偏头痛患者表现出去习惯化，而对照组则出现习惯化。疾病持续时间与CNV早期成分之间的Pearson相关系数为r = -0.767。疾病持续时间长的患者与疾病持续时间短的患者相比，去习惯化程度较低，截距较高。
疾病持续时间与注意力参数之间的相关性以及不断变化的去习惯化可解释为长期偏头痛患者预激活水平的增强。也许这种变化是转变为慢性偏头痛的一个先决条件。
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