Gorbsky G J
Department of Anatomy and Cell Biology, University of Virginia, Charlottesville 22908.
Bioessays. 1992 Feb;14(2):73-80. doi: 10.1002/bies.950140202.
The nature of the forces that move chromosomes in mitosis is beginning to be revealed. The kinetochore, a specialized structure situated at the primary constriction of the chromosome, appears to translocate in both directions along the microtubules of the mitotic spindle. One or more members of the newly described families of microtubule motor molecules may power these movements. Microtubules of the mitotic spindle undergo rapid cycles of assembly and disassembly. These microtubule dynamics may contribute toward generating force and regulating direction in chromosome movement.
有丝分裂中推动染色体移动的力的本质正开始被揭示。动粒是位于染色体主缢痕处的一种特殊结构，它似乎沿着有丝分裂纺锤体的微管在两个方向上进行移位。新描述的微管运动分子家族中的一个或多个成员可能为这些移动提供动力。有丝分裂纺锤体的微管经历快速的组装和拆卸循环。这些微管动态变化可能有助于产生力并调节染色体移动的方向。
