Semënov M V
Department of Biology, Yale University, New Haven, CT 06520-8103, USA.
J Theor Biol. 1996 Mar 21;179(2):91-117. doi: 10.1006/jtbi.1996.0052.
In this study, microtubules are regarded as polymers with positive free surface energy. The dynamics of such polymers is complex, consisting of equilibrium, non-equilibrium, and one-directional processes. This view of microtubules enables us to propose a new model of microtubule dynamics both in vitro and in vivo, and to draw a new conclusion on the role of GTP hydrolysis and calcium cations in microtubule polymerization. The study also offers a new model of chromosome movement in mitosis and a new model of the movement of motor proteins along microtubules. In the conclusion of the similarity and difference between microtubules and microfilaments is examined. We conclude that microfilaments, like microtubules, represent polymers with positive free surface energy, and that the movement of myosins along microfilaments can be realized in the same manner as the movement of motor proteins along microtubules.
在本研究中，微管被视为具有正自由表面能的聚合物。这类聚合物的动力学很复杂，包括平衡、非平衡和单向过程。这种对微管的观点使我们能够提出一个体外和体内微管动力学的新模型，并就GTP水解和钙阳离子在微管聚合中的作用得出新结论。该研究还提供了有丝分裂中染色体运动的新模型以及驱动蛋白沿微管运动的新模型。在结论部分，研究了微管和微丝之间的异同。我们得出结论，微丝与微管一样，代表具有正自由表面能的聚合物，并且肌球蛋白沿微丝的运动可以通过与驱动蛋白沿微管运动相同的方式实现。
