Kendell Steven F, Krystal John H, Sanacora Gerrard
Yale University School of Medicine, Department of Psychiatry, 333 Cedar Street, New Haven, CT 06510, USA.
Expert Opin Ther Targets. 2005 Feb;9(1):153-68. doi: 10.1517/14728222.9.1.153.
Advances made in diverse areas of neuroscience suggest that neurotransmitter systems, additional to the monoaminergic, contribute to the pathophysiology of mood disorders. This ever accruing body of preclinical and clinical research is providing increased recognition of the contribution made by amino acid neurotransmitters to the neurobiology of mood disorders. This review examines evidence supporting the role of GABA and glutamate in these processes and explores the potential to target these systems in the development of novel compounds; the viability of these agents for treatment-related co-morbidities will also be considered.
神经科学不同领域取得的进展表明，除单胺能神经递质系统外，其他神经递质系统也参与了情绪障碍的病理生理过程。这一不断积累的临床前和临床研究成果，使人们越来越认识到氨基酸神经递质在情绪障碍神经生物学中的作用。本综述考察了支持γ-氨基丁酸（GABA）和谷氨酸在这些过程中作用的证据，并探讨了在新型化合物研发中针对这些系统的潜力；还将考虑这些药物用于治疗相关合并症的可行性。
