Hannu Timo, Toskala Elina, Tuomi Timo, Sainio Markku
Finnish Institute of Occupational Health-Department of Occupational Medicine, Topeliuksenkatu 41 a A, FIN-02500, Helsinki, Finland.
Occup Med (Lond). 2005 Mar;55(2):142-4. doi: 10.1093/occmed/kqi043.
A case of acute permanent anosmia is described in a renovation worker during exposure to a waterproof coating chemical. The chemical consisted of several substances of which four (acetone, acrylates, butyl acetate and carbon disulfide) has been previously reported to induce hyposmia or anosmia in workers. Other aetiologies were clinically excluded but a large arachnoidea cyst in the frontal part of the left temporobasal fossa with possible compression of the left entorhinal cortex. The toxic aetiology of anosmia is supported by the acute onset and the temporal relationship with occupational exposure. The silent cyst as the cause of anosmia is improbable, but it may have had some contributory role. Our case illustrates both the challenges when clinically examining patients with work-related olfactory impairment and the importance of multi-disciplinary approach to such patients.
本文描述了一名装修工人在接触防水涂料化学品期间发生急性永久性嗅觉丧失的病例。该化学品由几种物质组成，其中四种（丙酮、丙烯酸酯、乙酸丁酯和二硫化碳）此前已有报道可导致工人嗅觉减退或嗅觉丧失。临床上排除了其他病因，但发现左颞叶基底部额叶有一个大的蛛网膜囊肿，可能压迫了左侧内嗅皮质。嗅觉丧失的中毒病因得到急性起病以及与职业暴露的时间关系的支持。无声囊肿作为嗅觉丧失的原因不太可能，但可能起到了一定的促成作用。我们的病例既说明了临床检查与工作相关嗅觉障碍患者时面临的挑战，也说明了对此类患者采取多学科方法的重要性。
